The invention provides an active-disturbance-rejection control parameter setting method used for a pH (Potential of Hydrogen) neutralization process. The method comprises the following steps that: establishing an initial active-disturbance-rejection controller structure, obtaining a closed loop transfer function expression corresponding to the initial active-disturbance-rejection controller structure, on the basis of a closed loop system quick convergence condition, carrying out formal transformation on the closed loop transfer function expression, and determining parameters to be set; carrying out setting processing on parameters to be set one by one, and determining the calculation way of each parameter to be set; and on the basis of an electric charge and carbide ion balance principle,establishing a pH neutralization model to realize the active-disturbance-rejection control of the pH neutralization process, and combining the calculation way for each determined parameter to be set in the active-disturbance-rejection controller to regulate the active-disturbance-rejection controller parameter of the pH neutralization process. An improved active-disturbance-rejection controller isused to realize the control of the pH neutralization process, and the system has high robustness and antijamming capability while system tracking performance is guaranteed. Compared with other active-disturbance-rejection controllers, the improved active-disturbance-rejection controller can reduce the amount of parameters to be set and optimize setting efficiency.