The invention provides a management and control system and a management and control method of terminal ports. The system includes: a remote scanning module, which is used for periodically scanning theports of all terminals through a network, and acquiring first port information associated with terminal IP; a terminal collection control module, which is used for periodically issuing a port information collection script and an information returning program to all online terminals; a terminal information receiving module, which is used for receiving second port information which is collected byall the terminal through the information collection script, is sent by the information returning program and is associated with the terminal IP; a port judging module, which is used for determining high-risk port information in the first port information and the second port information according to a preset high-risk port information list; and a security processing module, which is used for security processing for high-risk ports. The system can quickly obtain a large amount of port information, and quickly obtain the large amount of port information in a network through two manners of scanning and collection mutually complemented.