The embodiment of the invention provides strain calibration equipment for a large-scale aerospace structural test system, and belongs to the technical field of aerospace. The equipment comprises an upper computer and a calibration equipment box; the calibration equipment box is connected with the upper computer, and the calibration equipment box is connected to all channels of strain collection equipment through test cables in sequence; the strain collection equipment is loaded with upper computer software stored in the upper computer through model selection, and the channels of the strain collection equipment are calibrated. Since automatic calibration of single strain equipment can be achieved, automatic point change and automatic switching of standard strain are achieved, and data recording and processing are automatically achieved. Since fast unattended calibration of strain test equipment is achieved, the workload is reduced, the calibration efficiency is improved, and the equipment utilization rate is increased.