A capacitive-coupled chopper instrumentation amplifier includes a first chopper, a first gain stage, a capacitive isolation stage electrically coupled between inputs of the first gain stage and the first chopper, a second gain stage, a second chopper electrically coupled between outputs of the first gain stage and inputs of the second gain stage, clamping circuitry electrically coupled between theinputs of the first gain stage and a reference voltage rail, and a controller. The controller is configured to (a) detect a change in a first common-mode voltage exceeding a threshold value, the first common-mode voltage being a common-mode voltage at the inputs of the amplifier, and (b) in response to detecting the change in the first common-mode voltage exceeding the threshold value, cause theclamping circuitry to clamp the inputs of the first gain stage to the reference voltage rail.