The invention belongs to the technical field of biological medicines, in particular relates to a multi-target kinase inhibitor and a pharmaceutical composition containing the multi-target kinase inhibitor, and also relates to a preparation method and application of the multi-target kinase inhibitor. The structural general formula of the multi-target kinase inhibitor provided by the invention is shown in a formula (I), wherein the structure of R is selected from a formula (a), a formula (b), a formula (c), a formula (d), a formula (f) and the formula (d); the multi-target kinase inhibitor can effectively inhibit the enzymatic activity of RET, VEGFR3 and PDGFRA, and can effectively treat diseases which are regulated and controlled by multi-target kinase and are related to the abnormal signaltransduction pathway of the multi-target kinase, such as cancers of breast, respiratory tract, brain, reproductive organ, digestive tract, urinary tract, eye, liver, skin, head and/or neck, as well as distal metastatic cancers, such as lymphoma, sarcoma, leukemia and the like. The active ingredient of the pharmaceutical composition comprises the multi-target kinase inhibitor, and the weight percentage of the multi-target kinase inhibitor in the composition is 1-50%. (See the instruction for specific formulas.).