The invention provides a graphene modified safety shoe sole and a manufacturing method thereof. The graphene modified safety shoe sole comprises a component A, a component B, and graphene which is added to the component A and the component B, wherein the total adding amount of the graphene in the component A and the component B is 5-30 parts. The manufacturing method comprises the steps of modifying graphene, and correspondingly adding the modified graphene into the component A and the component B to prepare the shoe sole. The modified graphene obtained by the method is high in dispersing effect in polyurethane, so that the comprehensive performance of the safety shoe sole is improved; the polyurethane shoe sole prepared according to the method has the characteristics of being environmentally friendly, light, convenient, resistant to wearing, resistant to hydrolysis, resistant to static, and long in service life, and is applicable to long-term use in a terrible working environment.