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发明公开
CN109803662A 髓鞘再生疗法 无效 - 撤回

髓鞘再生疗法
摘要：
本发明包括施用髓鞘再生剂来治疗脱髓鞘疾患，诸如MS。公开了各种促进髓鞘再生、少突胶质细胞分化以及脱髓鞘疾患诸如MS的治疗的髓鞘再生组合物。在一方面，所述髓鞘再生组合物是具有髓鞘再生特性的选择性雌激素受体调节剂。在一方面，所述髓鞘再生组合物是GPR56的激动剂，所述GPR56是一种先前尚未被鉴定为髓鞘再生效应子的G蛋白偶联受体。
摘要（英）：

The invention comprises the administration of a remyelinating agent to treat a demyelinating condition, such as MS. Disclosed are various remyelinating compositions which promote remyelination, oligodendrocyte differentiation, and the treatment of demyelinating conditions such as MS. In one aspect, the remyelinating compositions are selective estrogen receptor modulators with remyelinating properties. In one aspect, the remyelinating compositions are agonists of GPR56, a G-protein coupled receptor which has not previously been identified as an effector of remyelination.

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