The invention discloses a segmented preparation method of a rhenium-niobium compound spraying pipe, and belongs to the technical field of refractory metal material powder metallurgy preparation. Forming covers at the upper lower and the lower end comprise niobium alloy modules for forming rhenium-niobium compound parts. The cover with rhenium powder is firstly formed through low-temperature isostatic pressing; at this time, rhenium component blanks are formed to achieve a certain strength, and the compactness reaches above 99%; as rhenium-niobium transition areas at the upper part and the lower part are located in a spraying pipe working low-temperature area, the direct machining formation can be performed; a rhenium basal body at the middle end is sintered at high temperature for furthercompactness to improve the metallurgical bonding strength, so that the mechanical performances meet the service requirements; and then, the machining formation is performed. Finally, the upper, middleand lower ends of a machined spraying pipe are welded through vacuum electronic beams as a complete rhenium-niobium compound spraying pipe.