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发明公开
CN109843902A 用于B型肝炎病毒感染的RNAi剂 审中-实审

用于B型肝炎病毒感染的RNAi剂
摘要：
本发明描述了用于抑制B型肝炎病毒基因表达的组合物和方法。本发明描述了用于抑制B型肝炎病毒基因表达的RNA干扰(RNAi)剂。本文所公开的所述HBV RNAi剂可例如通过使用缀合的靶向配体靶向细胞，诸如肝细胞。本发明还描述了包含一种或多种HBV RNAi剂和任选地一种或多种另外的治疗剂的药物组合物。将所述HBV RNAi剂体内递送至受感染的肝脏提供了对HBV基因表达的抑制以及对与HBV感染相关的疾病和病症的治疗。
摘要（英）：

Described are compositions and methods for inhibition of Hepatitis B virus gene expression. RNA interference (RNAi) agents for inhibiting the expression of Hepatitis B virus gene are described. The HBV RNAi agents disclosed herein may be targeted to cells, such as hepatocytes, for example, by using conjugated targeting ligands. Pharmaceutical compositions comprising one or more HBV RNAi agents optionally with one or more additional therapeutics are also described. Delivery of the described HBV RNAi agents to infected liver in vivo provides for inhibition of HBV gene expression and treatment ofdiseases and conditions associated with HBV infection.

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