The invention discloses a sand-sticking preventing device for a horizontal well cable transmission hydraulic pumping tool, and a method of the sand-sticking preventing device. The sand-sticking preventing device comprises a magnetic positioning device, a perforation gun string, a bridge plug putting and setting tool and a bridge plug and a sand levee clearing tool; the sand levee clearing tool isarranged in a casing pipe and sequentially connected with the bridge plug, the bridge plug putting and setting tool, the perforation gun string and the magnetic positioning device through a cable, andthe sand levee clearing tool is powered by the cable to clear a sand levee in the casing pipe by rotating at a high speed. According to the sand-sticking preventing device, the pumping failure or drilling-sticking accident caused by sand setting in the casing pipe of a horizontal well can be effectively avoided, and thus a tool string in the casing pipe of the horizontal well is pumped safely andefficiently at the high speed.