The present invention discloses a direct current power supply protection circuit and an electronic device. A first protection branch comprises a semiconductor discharge tube and a transient state suppression diode which are connected in series, a first DC circuit is accessed into a positive pole voltage, and a second DC circuit is accessed into a negative pole voltage; when a forward voltage between the first DC circuit and the second DC circuit is larger than a first preset voltage, the transient state suppression diode is conducted with the semiconductor discharge tube, and the first presetvoltage is the superposition of the clamp voltage of the transient state suppression diode and the breakover voltage of the semiconductor discharge tube; when a backward voltage between the first DC circuit and the second DC circuit is larger than a second preset voltage, the transient state suppression diode and the semiconductor discharge tube are two forward diodes connected in series for conduction. The direct current power supply protection circuit and the electronic device can reduce the residual voltage of the direct current power supply protection circuit, can reduce the chip loss andarea, can reduce the cost of the direct current power supply protection circuit and can achieve the effect of the miniaturization and the reverse connection prevention multiple protection of the direct current power supply protection circuit.