The invention provides an auto disturbance rejection parameter setting method for a pH neutralization process. The method comprises the following steps that: an initial auto disturbance rejection controller structure is established, a closed loop transfer function expression corresponding to the initial auto disturbance rejection controller structure is obtained, format conversion is carried out on the closed loop transfer function expression based on rapid convergence conditions of a closed loop system, and to-be-set parameters are determined; the to-be-set parameters are set one by one and acalculation mode of each to-be-set parameter is determined; and on the basis of the charge and carbide ion balance principle, a pH neutralization model is established to realize auto disturbance rejection control of the pH neutralization process, auto disturbance rejection controller parameters of the pH neutralization process are adjusted by combining the determined calculation mode of each to-be-set parameter in the auto disturbance rejection controller. Since the pH neutralization process is controlled by using an improved auto disturbance rejection controller, the high robustness and anti-interference ability are realized while the tracking performance of the system is ensured. Compared with other auto disturbance rejection controllers, the auto disturbance rejection controller enables the number of to-be-set parameters to be reduced and the setting efficiency to be improved.