The invention relates to an application of a hydrotalcite-based composite catalyst in preparation of amine compounds through hydroammonolysis of aldehyde or ketone compounds. According to the invention, hydrotalcite or hydrotalcite-like compound transition metal elementary substances are used as active components which are used as catalysts, and aldehyde or ketone compounds and ammonia gas are catalyzed in a hydrogen atmosphere to be subjected to an ammonolysis reaction, so that amine compounds are prepared. And high conversion rate of the aldehyde or ketone compounds and high selectivity of the target product amine compound are realized by adjusting conversion conditions such as reaction temperature, retention time and catalyst dosage. The catalyst provided by the invention is applied tothe reaction for preparing the amine compound by hydroammonolysis of aldehyde or ketone compounds, and has the characteristics of low price of the catalyst, high yield of a target product, good stability of the catalyst and the like.