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发明公开
CN110003241A 一种拉氧头孢母核的制备方法 无效 - 驳回

一种拉氧头孢母核的制备方法
摘要：
本发明公开了一种拉氧头孢母核的制备方法，包括以下制备步骤：氧头孢烯母核作为原料，与1-甲基-5-巯基四氮唑发生反应制得（001），（001）再脱去7位保护基制得（002），（002）和氯气和甲醇锂反应制得最终产物拉氧头孢母核。本发明公开的拉氧头孢母核的制备方法具有成本低，合成操作简单，易于工业化的优点，且本发明的产品纯度（HPLC)可以达到99%，在纯度方面有很大优势。
摘要（英）：

The invention discloses a preparation method of latamoxef mother nucleus, comprising the following preparation steps: oxacephem mother nucleus, which is used as a raw material, reacts with 1-methyl-5-mercaptotetrazole to prepare (001); 7 protective groups are removed from (001) to prepare (002); and (002) reacts with chlorine and lithium methoxide to prepare the final product latamoxef mother nucleus. The latamoxef mother nucleus preparation method disclosed in the invention has advantages of low cost, simple synthetic operation and easy industrialization. In addition, the product purity (HPLC) can reach 99%. The preparation method has great advantages in the aspect of purity.

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