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发明公开
CN110003343A 牛传染性鼻气管炎病毒多表位重组嵌合蛋白及其应用 有权

牛传染性鼻气管炎病毒多表位重组嵌合蛋白及其应用
摘要：
本发明提供牛传染性鼻气管炎病毒多表位重组嵌合蛋白及其应用。所述重组嵌合蛋白由破伤风毒素通用T细胞表位多肽P2，牛传染性鼻气管炎病毒gB上的抗原表位gB-A、gB-B，牛传染性鼻气管炎病毒gC上的抗原表位gC-A、gC-B，牛传染性鼻气管炎病毒gD上的抗原表位gD-A、gD-B、gD-C以及牛IL-6之间通过刚性Linker串联而成。本发明提供的牛传染性鼻气管炎病毒多表位重组嵌合蛋白诱导产生的抗牛传染性鼻气管炎病毒的抗体水平显著高于其他对照组，表明该重组嵌合蛋白具有良好的免疫原性。
摘要（英）：

The invention provides a bovine infectious rhinotracheitis virus multi-epitope recombinant chimeric protein and an application thereof. The recombinant chimeric protein is formed by rigid linker series connection of a tetanus toxin general T cell epitope polypeptide P2, a bovine infectious rhinotracheitis virus gB antigen epitopes gB-A and gB-B, bovine infectious rhinotracheitis virus gC antigen epitopes gC-A and gC-B, bovine infectious rhinotracheitis virus gD antigen epitopes gD-A, gD-B and gD-C and bovine IL-6. The anti-bovine infectious rhinotracheitis virus antibody level induced by the bovine infectious rhinotracheitis virus multi-epitope recombinant chimeric protein provided by the invention is significantly higher than that of other control groups, and the recombinant chimeric protein is indicated to have good immunogenicity.

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