The invention belongs to the technical field of intelligent medium heat exchange and temperature control construction of civil engineering, and provides an intelligent control system and method for medium heat exchange. The intelligent control system for the medium heat exchange comprises a heat exchange device, a heat exchange auxiliary device and control devices; a plurality of integrated flow temperature control devices are arranged in a flow temperature medium integrated control cabinet; the flow temperature medium integrated control cabinet and a data acquisition, analysis and feedback intelligent control cabinet are arranged in a heat exchange medium loop; the control devices are used for controlling heat exchange media to finish heat exchange with a target area through the loop, theheat exchange auxiliary device and the heat exchange device. The intelligent control system has the beneficial effects that, by adopting intelligent PID algorithm control, the maximum temperature control in the heat exchange process, coordinated gradient control over the spatial temperature variation rate in the whole process of heat exchange of the target area, and control over the abnormal temperature control conditions in the heat exchange process of the target area are performed through a gradient closed-loop intelligent learning control method, and various emergencies and abnormalities can be handled effectively.