The invention discloses an air separation equipment energy consumption monitoring system based on hybrid modeling, which is used for carrying out real-time monitoring and operation optimization on airseparation equipment. The system comprises a mechanism statistics hybrid modeling module, an energy consumption calculation module and a product extraction rate calculation module. The product extraction rate and an equipment energy consumption value are transmitted to a control station and a storage system through a field bus. The method aims to overcome the defects that an existing space division model is low in online operation efficiency and poor in model precision, through combining with a high-expansibility and high-precision mechanism model and a high-efficiency statistical model whichcan use a large amount of production historical data, a high-precision and high-efficiency energy consumption monitoring and mixing model of the air separation equipment is established. On the basis,the space division equipment energy consumption monitoring system based on hybrid modeling is realized. The system preferably combines the high-precision advantage of a mechanism model and the high-efficiency advantage of a statistical model. The accuracy is high, the operation speed is high, and thus the efficient and accurate energy consumption monitoring effect is achieved.