The invention relates to a chemical mixture serious eye damage and eye irritation dangerousness estimation method. The method mainly solves the problem that no chemical mixture serious eye damage andeye irritation dangerousness estimation method exists in the prior art. The chemical mixture serious eye damage and eye irritation dangerousness estimation method comprises the steps that (1) the mixture can be sorted through the serious eye damage/eye irritation data of the ingredients in the mixture if the mixture is not subjected to an animal eye damage and irritation test, and no data of the similar mixture can be taken for reference; (2) computation is conducted by adopting the following formula: the formula is shown in the description; and (3) the estimation result is determined to be the sorts of 'serious eye damage/eye irritation, sort 1' and 'serious eye damage/eye irritation, sort 2' according to the judgment standard that whether the final computational result is larger than orequal to 1 or not. The method can be applied to estimation of chemical mixture serious eye damage and eye irritation dangerousness.