The invention relates to a leakage source positioning method and device based on a concentration time sequence and computer equipment. The method comprises the following steps: constructing an objective function model associated with gas concentration information according to a preset atmospheric diffusion model; monitoring the concentration information of the current gas, and obtaining a calculated concentration sequence of the atmospheric diffusion model according to the concentration information of the current gas and the atmospheric diffusion model; calculating a concentration sequence according to the objective function model, the concentration information of the current gas and the atmospheric diffusion model to obtain an objective function model calculation value; and determining the leakage source intensity and the leakage source position according to the calculated value of the objective function model. According to the method, the leakage source strength and the leakage source position can be obtained according to the calculated value of the objective function model, and accurate positioning of the hazardous chemical gas leakage source is achieved.