The invention discloses a magnetic coupling resonant wireless energy transmission system based on an E-type power amplifier and a four-coil structure. The magnetic coupling resonant wireless energy transmission system comprises a gate pole driving signal source (1), a power transistor (2), a drain direct-current input (3), a parallel capacitor and LC resonant circuit (4), a second-grade coil (5),a third-grade coil (6), a receiving coil (7) and an output load (8), wherein the gate pole driving signal source (1) is connected to a grid of the power transistor (2); the drain direct-current input(3) is connected to the drain of the power transistor (2); the drain output of the power transistor (2) is transmitted to the second-grade coil (5) through the parallel capacitor and LC resonant circuit (4); the second-grade coil (5) transmits to the third-grade coil (6); the third-grade coil (6) transmits to the receiving coil (7); and the receiving coil (7) is connected to the output load (8). The magnetic coupling resonant wireless energy transmission system has the advantages of simplified structure, high transmission efficiency and low cost.