The invention aims to provide an individual accurate health preserving method based on gene sequencing technology. For realize the purpose, the individual accurate health preserving method based on the gene sequencing technology is characterized by comprising the following steps of (1), performing whole genome sequencing on an individual for obtaining total heredity mutation information of the individual; (2), constructing a heredity mutation information database; (3), analyzing and predicting an individual health change trend through comparing the total heredity mutation information of the individual with the database constructed in the step (2); and (4), adopting an active health preserving measure behavior according to the analyzed and predicted individual health change trend. Accordingto the method of the invention, the total heredity mutation information of the individual can be obtained by means of whole genome sequencing technology, and then according to database information, through performing comprehensive analysis on the collected information, the effective pathogenic heredity mutation is screened, and a physiological change caused by mutation and a latent result are defined. The individual accurate health preserving method has advantages of advanced time, active behavior, accurate measure and high effect.