The invention relates to patch and a preparation method thereof. The patch comprises a backlining layer, a patch layer and a microneedle array, wherein the patch layer is positioned above the backlining layer; the microneedle array is positioned above the patch layer; the microneedle array comprises a plurality of microneedles; the plurality of microneedles are provided with needle column ends andneedle tip ends; the needle column ends are fixed on the patch layer; the needle tip ends are far away from the patch layer; the patch layer is mainly prepared from the following raw materials: a first medicine, a pressure-sensitive adhesive and a first auxiliary material; and each microneedle is mainly prepared from the following raw materials: a second medicine, a base material and a second auxiliary material. The patch provided by the invention can realize combined release of one or more medicines, and has high medicine delivery efficiency and high bioavailability.