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发明公开
CN110314164A JMJD3抑制剂GSK-J4·HCL在制备抗结肠炎药物中的应用 审中-实审

JMJD3抑制剂GSK-J4·HCL在制备抗结肠炎药物中的应用
摘要：
本发明属医药技术领域，涉及JMJD3抑制剂GSK-J4·HCL在制备抗结肠炎药物中的应用。本发明通过LPS和尼日利亚菌素(Nigricin)刺激集落刺激因子诱导的骨髓来源巨噬细胞(BMDM)炎症模型实验证实了GSK-J4·HCL显著抑制BMDM炎症因子释放；通过葡聚糖硫酸钠盐(DSS)诱导的C57小鼠结肠炎模型实验证实了GSK-J4·HCL显著改善结肠炎炎小鼠症状，具有良好的抗结肠炎作用。本发明涉及的化合物GSK-J4·HCL可用于制备抗结肠炎药物，为寻求安全有效的抗结肠炎药物提供了一种新的来源。
摘要（英）：

The invention belongs to the technical field of medicine, and relates to application of a JMJD3 inhibitor GSK-J4.HCL in preparing anti-colitis drugs. LPS and nigericin stimulate a bone marrow-derivedmacrophage (BMDM) inflammation model experiment induced by a colony stimulating factor, it is verified that the GSK-J4.HCL significantly inhibits the release of BMDM inflammatory factors; through a C57 mouse colitis model experiment induced by dextran sodium sulfate (DSS), it is verified that the GSK-J4.HCL significantly improves the symptoms of colitis mice, and has a good anti-colitis effect. The related compound GSK-J4.HCL can be used for preparing the anti-colitis drugs, and provides a new source for seeking safe and effective anti-colitis drugs.

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