The invention discloses a method for removing manganese in a vanadium-containing leaching solution, and belongs to the technical field of vanadium metallurgy. The method comprises the following stepsof, S1, taking an acidic vanadium-containing leaching solution, adding an ammonium carbonate solution according to 1.9-3.0:1 of molar ratio of carbonate ions to manganese ions, stirring and reacting,and filtering to obtain filtrate and filter residues; S2, adding water into the filter residues, heating to 65-75 DEG C, stirring and reacting, and filtering to obtain the filtrate; S3, uniformly mixing the filtrate obtained in S1 and S2, adjusting the pH value to 1-3, heating to 90-100 DEG C, stirring and reacting, and filtering to obtain a precipitate; and S4, drying and calcining the precipitate to obtain the high-purity V2O5. According to the method, the impurity manganese in the high-manganese vanadium-containing leaching solution can be removed in one step, the manganese removal rate canreach 99% or higher, the total-process vanadium yield can reach 80% or higher, and the purity of a prepared V2O5 product can reach 99.9%; and the method is short in production process, simple in process, small in pollution and low in cost.