The invention relates to the technical field of mobile power supplies, in particular to a mobile power supply charging module. The power supply comprises a power supply body; a rectangular groove is formed in the front surface of the power supply body; wire grooves are formed in the two sides of the interior of the rectangular groove; a first power line and a second power line are arranged on theinner sides of left and right wire grooves respectively; the bottom end of the first power line is electrically connected with a USB connector; and the bottom end of the second power line is connectedwith a flow dividing line. By arranging the first power line, the second power line, the USB connector, the flow dividing line, the Micro USB connector, a Lightning joint, a Type-C joint, a cover plate, a USB interface and a dustproof plate, the overall function of the power supply body is enhanced; the mobile power supply charging module is enabled to have the advantages of complete wiring and self-dust prevention; and the problems is solved that a conventional mobile power supply is single in structure, so troubles are brought to an emergency charging user who only carries a mobile phone, and dust cannot be prevented from entering a charging interface, which causes external dust or fluff to enter the charging interface.