The invention discloses application of phenolic compounds. The phenolic compounds are shown in the formulas (I)-(III). The phenolic compounds are used for preparing anti-allergic drugs. Through research, it is found that the three phenolic compounds have strong inhibition effects on degranulation of mast cells, and can be used for preparing anti-allergic drugs, especially anti-food-allergy drugs;through fermentation of deep-sea fungi, namely penicillium chrysanthum which has rich sources, the three substances with strong anti allergic activity are obtained at the same time, compared with directional synthesis during which a variety of by-products are produced, the preparation method is more suitable for industrial production and natural resources are rationally utilized.