The invention belongs to the technical field of rehabilitation training and treatment equipment, and particularly relatesto a synchronous multimode treatment system based on the VR-TMS technology. Theprovided synchronous multimode treatment system comprises a VR device, a TMS device, a monitoring device and a control device, the VR device is used in combination with the immersive experience of scenario setting, audio-visual stimulation is applied, a nerve activity state is regulated, the control device is combined, the nerve activity information is obtained, time nodes are flexibly controlledand selected through the control device, and the TMS device is activated for synchronous treatment of two modes of virtual reality and transcranial magnetic stimulation. Based on the principle of neural plasticity, the synchronous multimode system integrates the two modes of VR-TMS to stimulate the specific brain area of depression, the neural plasticity is improved, the two modes of interventionand cumulative effects are integrated, and the therapeutic effect on functional and organic mental pathological changes is improved.