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发明公开
CN110396504A 一种具有肿瘤靶向性的重组痘苗病毒及其制备方法、用途 无效 - 驳回

一种具有肿瘤靶向性的重组痘苗病毒及其制备方法、用途
摘要：
本发明公开了一种具有肿瘤靶向性的重组痘苗病毒及其制备方法、用途，该重组痘苗病毒包括将胞嘧啶脱氨酶基因序列插入痘苗病毒的基因组中得到的能够表达胞嘧啶脱氨酶蛋白的重组痘苗病毒，所述痘苗病毒为天坛株广9，所述胞嘧啶脱氨酶基因编码的是酵母胞嘧啶脱氨酶，胞嘧啶脱氨酶基因序列如SEQ ID NO：1所示。本发明提供的重组痘苗病毒能够大量表达胞嘧啶脱氨酶蛋白，且表达的胞嘧啶脱氨酶蛋白活性高，能够有效将5-FC前体转变为化疗药物5-FU。
摘要（英）：

The invention discloses recombinant vaccinia virus with tumor targeting and a preparation method and application thereof. The recombinant vaccinia virus expressing cytosine deaminase protein is obtained by inserting a cytosine deaminase gene sequence into vaccinia virus genome. The vaccinia virus is the Tian Tan strain G9, the cytosine deaminase gene encodes yeast cytosine deaminase, and the cytosine deaminase gene sequence is shown in SEQ ID NO: 1. The recombinant vaccinia virus can express the cytosine deaminase protein in a large amount, and the expressed cytosine deaminase protein has highactivity, and can effectively convert a 5-FC precursor into a chemotherapeutic drug 5-FU.

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