The invention provides a case and plug-in locking mechanism, which includes a case and a plug-in. Several buckle posts are installed on the inner side of a front panel of the plug-in. The case includes a case body and a locking trigger strip. At least one of upper and lower panels of the case body is provided with a groove, and several plug-in holes for the buckle posts of the plug-in to enter andexit are arranged in the outer vertical surface of the groove. The locking trigger strip is installed in the groove. The locking trigger strip is of an L-shaped structure, wherein one side is close to a bottom panel of the groove, and the other side is close to the outer vertical surface of the groove and is provided with a plurality of locking holes corresponding to the plug-in holes. An eccentric rotating device is arranged at one end of the groove to control the movement of the locking trigger strip in the groove, and a power trigger switch triggered by the moving contact of the locking trigger strip is arranged at the other end. The problem that the plugging of the plug-in is complicated in the prior art is solved.