The invention belongs to the technical field of operation load induced ground subsidence prevention and control, and provides a multi-operation load induced ground subsidence prevention and control device for a karst cave marsh gas stratum. The device can simulate ground subsidence caused by multi-operation loads under different operation working conditions over and under the urban high-compact district, accurate ground subsidence data is obtained, and ground subsidence disasters are effectively prevented and controlled. The influence of the karst cave contained high-pressure marsh gas stratumof a subway operation region in a city highly compact district on ground subsidence can be simulated, the ground subsidence distribution rules of the karst cave contained high-pressure marsh gas stratum can be obtained, the subway construction risk of the karst cave contained high-pressure marsh gas stratum is lowered, and the construction cost is lowered; ground subsidence data caused by subwayoperation in a city highly compact district under different rainfall conditions can be obtained, various risks caused by city subway construction in the flood prevention period are lowered, the time limit of a project is shortened, and the subway construction safety is ensured.