The invention discloses a large-scale chicken culturing farm disinfection device, which comprises a chicken cage, a decontamination device, a water-supplying ultraviolet disinfection device, disinfecting aerosol nozzles and a disinfectant supply device; a plurality of disinfecting aerosol nozzles can be provided and equidistantly distributed in the top of a chicken cage; the decontamination deviceis disposed under the chicken cage, and the decontamination device comprises a scraper plate, a driving mechanism and a clearing and sterilizing tank with an open top; one end of the clearing and sterilizing tank is provided with a clearing door; the water-supplying ultraviolet disinfection device comprises a filter, a sterilization box, an outlet pipe, a lower float valve, an inlet pipe, and a float ball valve; and the disinfectant supply device comprises a disinfectant tank and a pressure pump. The invention discloses the large-scale chicken culturing farm disinfection device, which can completely disinfect large-scale farms through chicken cage disinfection, drinking water disinfection and fecal disinfection, avoids blind spots of disinfection, comprehensively protects chicken farms, and improves work efficiency.