The invention discloses a five-component synthesis method of nicotinoyl imine amide derivatives in the field of organic chemical synthesis. According to the synthesis method, a copper compound is usedas a catalyst, and in the presence of ligands and in organic solvents, five components including an O-acetyl aryl ethyl ketoxime derivative (II), aryl aldehyde (III), sulfonyl azide (IV), arylamine (V) and alpha-carbonyl terminal alkyne (VI) are subjected to reactions to obtain the nicotinoyl imine amide derivatives (I) with diversified structures. The method has the advantages of high product yields, high purity, high atom economy and the like, has good scientific research value and application prospects, provides a brand-new route for the preparation of the compounds, can play an importantrole in the fields of drug intermediates, farm chemical intermediates and the like, reduces the production cost, and has good application value and potential in industry and scientific research.