The invention discloses an image encryption method for a hyper-chaotic pseudo-random sequence, and the method comprises the steps: firstly selecting a fourth-order hyper-chaotic Chen system, generating the hyper-chaotic pseudo-random sequence, and enabling an initial value of the hyper-chaotic pseudo-random sequence to serve as a secret key; secondly, preprocessing the image, defining the row-column transformation relation of the image, further disturbing the row and column of the image, and determining parameters of the row-column transformation relation dynamically by a hyperchaotic pseudo-random sequence; defining the transformation relation of the image pixel values again, wherein the parameters of the transformation relation are dynamically determined by the hyper-chaotic pseudo-random sequence; and finally, encrypting the transformed image to obtain an encrypted image. According to the invention, a pseudorandom sequence with better initial sensitivity, randomness, stability, autocorrelation and other characteristics can be flexibly and conveniently generated, so that a better secret key is obtained; and the positions and pixel values of the image pixels are dynamically disturbed, so that the correlation of the image is further reduced, the secrecy effect is further improved, the higher requirement of a user on image encryption can be met, and the practicability is higher.