The invention discloses a pH-response tumor targeted cancer resistant medicine carrier and a preparation method thereof. Polyaspartate (PASP) is used as a raw material, through an amidation reaction,tyrosine (Tyr) is grafted to a polyaspartate side chain, a polyaspartate-tyrosine grafted substance having amphipathicity is formed, and the grafted substance can be self-assembled in a water phase toform a nanometer micelle; and based on the nanometer micelle, through the amidation reaction, ethylenediamine is grafted to a polyaspartate side chain, the ethylenediamine is used as a bridge, hyaluronic acid (HA) is grafted to be used as a target ligand, and target action on cancer cells is given to the micelle. Curcumin is used as a hydrophobic medicine model, doxorubicin hydrochloride is usedas a hydrophilic medicine model, simultaneous loading on two medicines is realized, and besides, the medicine loading rate is high. The medicine carrier has the following advantages that the medicinecarrier can load two kinds of medicines simultaneously, is high in the medicine loading rate, has obvious pH response, has targeting properties on the cancer cells, and is good in biocompatibility, low in cost and simple and convenient to operate.