The invention provides a method and system for managing a personal database. The method comprises the steps: setting attributes for the personal database based on setting of a user interface; uploading to-be-uploaded data to a personal database through a preset uploading interface based on the personal database attribute, and processing the data in the personal database; based on authority management, realizing sharing of personal data; and setting a corresponding calculation formula based on the index relationship between the public data and the personal data, and storing a calculation resultin a public database. According to the system and the method, the specialty and flexibility of personal data management are improved, and the user can customize personal special data according to ownresearch requirements and can interact with the public database at the same time, and the sharing requirements of personal research results are met while personal personalized application is realized.