The invention discloses a method for calculating deformation and internal force of a buried pipeline caused by local foundation subsidence. The method comprises the following steps: (1) determining physical and mechanical parameters and section geometrical parameters of the buried pipeline; (2) determining physical and mechanical parameters of a soil body; (3) determining local foundation subsidence shape parameters; (4) obtaining the additional stress of the buried pipeline caused by local foundation subsidence according to an empirical formula; (5) calculating the additional deformation of the buried pipeline according to the additional stress; and (6) calculating the bending moment and the shearing force of the buried pipeline by adopting an Euler Bernoulli beam theory according to theadditional deformation of the buried pipeline. Aiming at the local foundation subsidence condition for the first time, the method provides the buried pipeline deformation calculation formula based onthe non-continuous soil body, can well design buried pipelines of similar engineering, evaluates operation safety of the buried pipelines, enriches research on the aspect of pipe-soil interaction of the buried pipelines, and supplements theories in the aspect related to buried pipeline engineering design.