The invention discloses an electric heating simulation heat source for a general purpose isotope heat source. The electric heating simulation heat source comprises a heating element, an electrical insulation layer, a sealing layer, an impact buffer layer, a thermal insulation layer, an atmospheric ablation layer, a loading channel, a power supply lead channel, a wire collecting end, a reinforcingplate, a reinforcing plate screw, a temperature measuring thermocouple and a temperature measuring thermocouple lead channel. The electric heating simulation heat source is developed according to performance parameter of the general purpose heat source (GPHS) of the United States and can be used for a non-nuclear unit test of an isotope power supply system, and meanwhile, the nuclear security andthe test result effectiveness are guaranteed; a problem of poor equivalence of an existing electric heating simulation heat source and the real isotope heat source in the aspects of internal structure, heat distribution, temperature distribution and the like is overcome, the domestic blank is filled, and a technical basis is laid for development of high-power isotope power supply in China.