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发明公开
CN110627793A 一种喷昔洛韦与3,5-二羟基苯甲酸共晶及其制备方法 有权

一种喷昔洛韦与3,5-二羟基苯甲酸共晶及其制备方法
摘要：
本发明公开了一种喷昔洛韦与3,5-二羟基苯甲酸共晶及其制备方法。这种喷昔洛韦与3,5-二羟基苯甲酸共晶中，喷昔洛韦与3,5-二羟基苯甲酸的摩尔比为1:1。这种喷昔洛韦与3,5-二羟基苯甲酸共晶的制备方法工艺简单，结晶过程易于控制，重现性好，适用于工业化生产。该喷昔洛韦与3,5-二羟基苯甲酸共晶较喷昔洛韦具有较快的溶出速率和较大的表观溶解度，有利于提高喷昔洛韦的生物利用度，为成功开发出喷昔洛韦的口服制剂和液体制剂提供物质基础。
摘要（英）：

The invention discloses a penciclovir and 3,5-dihydroxybenzoic acid eutectic crystal and a preparation method thereof. In the penciclovir and 3,5-dihydroxybenzoic acid eutectic crystal, the molar ratio of penciclovir to 3,5-dihydroxybenzoic acid is 1:1. The preparation method of the penciclovir and 3,5-dihydroxybenzoic acid eutectic crystal is simple in process, the crystallization process is easyto control, the reproducibility is good, and the penciclovir and 3,5-dihydroxybenzoic acid eutectic crystal is suitable for industrial production. Compared with penciclovir, the penciclovir and 3,5-dihydroxybenzoic acid eutectic crystal has the advantages that the dissolution rate is higher, the apparent solubility is higher, the bioavailability of the penciclovir is favorably improved, and a material basis is provided for successfully developing oral preparations and liquid preparations of penciclovir.

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