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发明公开
CN110638807A 局部镇痛用药物组合物、其制备方法及其应用 审中-实审

局部镇痛用药物组合物、其制备方法及其应用
摘要：
本发明关于镇痛用药物组合物，特别是关于一种局部镇痛用药物组合物及其应用，所述局部镇痛用药物组合物包括(i)有效含量的木犀草素；(ii)有效含量的至少一种具有结构式(1)的杂吲哚衍生物或其非毒性药理学上可允许的盐；本申请还分别提供了包含所述局部镇痛用药物组合物的镇痛剂和镇痛用纳米脂质体制剂。所述局部镇痛用药物组合物对疼痛、特别是神经性疼痛和/或纤维肌痛症具有强的镇痛作用，其镇痛效果优于度洛西汀，但其毒性小于度洛西汀，以本发明所述局部镇痛用药物组合物作为效用成分制备镇痛用纳米脂质体，可以获得较好的粒径控制和质量控制，在疼痛的预防和治疗方面具有良好的应用潜力。
摘要（英）：

The invention discloses a medicine composition for analgesia, particularly relates to a medicine composition for local analgesia and application of the medicine composition. The medicine composition for the local analgesia comprises (i) luteolin having effective content; and (ii) at least one miscellaneous indole derivative which has effective content and has a structural formula (1) or non-toxicpharmacologically-acceptable salt. The invention also separately provides analgesics including the medicine composition for the local analgesia and a nano-liposome preparation for analgesia. The medicine composition for the local analgesia has a strong analgesic effect on pain, in particular to neuropathic pain and/or fibromyalgia syndrome, and the analgesic effect of the medicine composition is superior to that of duloxetine while the toxicity of the medicine composition is inferior to that of duloxetine. The medicine composition for the local analgesia disclosed by the invention as an effective ingredient is used for preparing the nano-liposome for analgesia, and better control of grain sizes and quality can be achieved, and therefore, the medicine composition has a good application potential on prevention and treatment of the pain.

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