The invention discloses a robust unit combination method considering operation risk and demand response, and the method comprises the following steps: 1, building an operation risk model based on a statistical method according to wind power historical data; and 2, based on the operation risk model in the step 1, bringing the demand response based on the time-of-use electricity price into the established robust unit combination model considering the operation risk, and solving the robust unit combination model by adopting a Benders decomposition method and a column constraint generation method(C & CG).