The invention discloses a method for preparing a chiral allyl amine compound with high chemical and stereoselectivity. The method comprises the steps: dissolving 1,3-conjugated diene and amine in an organic solvent under the action of a metal reagent Ni(COD)2, a chiral diphosphine ligand and an acid additive, carrying out a reaction, and carrying out column chromatography separation and purification to obtain the chiral allyl amine compound. The method disclosed by the invention can be used for efficiently synthesizing the chiral allyl amine compound, is mild in reaction condition and wide insubstrate range, and has excellent regioselectivity, chemical selectivity and stereoselectivity. For an amine substrate containing two nucleophilic sites, the reaction sites can be well identified, and the ee value is as high as 99%. In addition, gram-scale amplification can be carried out in the reaction, and the catalyst load can be reduced to 1% or less. The method can also efficiently react with desloratadine and other drug molecules, and a new method is provided for derivatization of drug molecules and synthesis of complex drug molecules.