The embodiment of the invention discloses a positioning method and device for a label anti-counterfeiting area and marking equipment. The positioning method comprises the steps of acquiring a first position parameter and a first angle parameter of a target label on a material belt under a camera coordinate system; acquiring a second position parameter and a second angle parameter of a target anti-counterfeiting area on the target label under a label coordinate system; according to the first position parameter, acquiring the second position parameter, the first angle parameter and the second angle parameter, a third position parameter and a third angle parameter of the target anti-counterfeiting area under the camera coordinate system,wherein the third position parameter and the third angleparameter reflect the position of the target anti-counterfeiting area. In this way, the anti-counterfeiting area can be effectively positioned.