利索-全球专利检索

  1. 登录
  2. 注册
发明公开
CN110799204A 治疗肺高血压的恩扎妥林和脆性组氨酸三联体(FHIT)增加剂 审中-实审

治疗肺高血压的恩扎妥林和脆性组氨酸三联体(FHIT)增加剂
摘要：
本发明提供了使用诸如恩扎妥林等增加FHIT活性的药剂来治疗或预防肺高血压和肺气肿的方法。包括使用FHIT和/或BMPR2的水平和检查FHIT和/或BMPR2中的突变以选择患者进行治疗或以监测治疗有效性的方法。本发明是基于以下证据：通过恩扎妥林预防和逆转在动物模型系统中诱导的肺高血压，并且恩扎妥林通过上调FHIT和/或BMPR2来发挥作用。
摘要（英）：

The present invention provides methods for treatment or prevention of pulmonary hypertension and emphysema using agents that increase activity of FHIT, such as Enzastaurin. Included are methods for using levels of FHIT and/or BMPR2, and checking for mutations in FHIT and/or BMPR2, to select patients for treatment or to monitor effectiveness of treatment. The invention is based on evidence that byEnzastaurin prevents and reverses pulmonary hypertension induced in animal model systems, and that it acts by up-regulation of FHIT and/or BMPR2.

0/0