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发明公开
CN110840856A 一种含利格列汀的组合物及其应用 无效 - 撤回

一种含利格列汀的组合物及其应用
摘要：
本发明涉及医药技术领域，具体涉及一种含利格列汀的组合物及其应用。组合物由活性成分和药用辅料组成，其中活性成分为利格列汀，药用辅料为甘露醇、预胶化淀粉和硬脂酸镁；组分按重量计：利格列汀2-5％，甘露醇72-90％g，预胶化淀粉5％-20％g，硬脂酸镁0.5-1.5％。组合物通过包衣制成胃溶型薄膜包衣片，薄膜包衣材料为组合物重量的2-3％。本发明中通过减少共聚维酮、玉米淀粉的使用，可以得到一种辅料种类少、工艺简单，且能达到和原研溶出相近甚至优于原研溶出的利格列汀片。
摘要（英）：

The invention relates to the technical field of medicine, in particular to a composition comprising linagliptin and application thereof. The composition comprises an active ingredient and pharmaceutical excipients, wherein the active ingredient is linagliptin, and the pharmaceutical excipients include mannitol, pregelatinized starch and magnesium stearate; by weight, linagliptin accounts for 2-5%,mannitol accounts for 72-90% g, pregelatinized starch accounts for 5-20% g, and magnesium stearate accounts for 0.5-1.5%. The composition is coated to obtain gastric-soluble film-coated tablets, anda film coating material accounts for 2-3% of the weight of the composition. According to the invention, the usage of the copovidone and corn starch is lessened, so that linagliptin tablets having fewer excipients, made by means of a simple process, and similar to or even better than the original drugs in terms of dissolution can be obtained.

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