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发明公开
CN110840898A 光稳定化药物组合物及其制备方法和制药用途 有权

光稳定化药物组合物及其制备方法和制药用途
摘要：
本发明涉及光稳定化药物组合物及其制备方法和制药用途。具体地，本发明提供的药物组合物包含劳拉西泮结晶，以及药用辅料；所述劳拉西泮结晶使用Cu-Kα辐射，在以2θ角度表示的粉末X-射线衍射图谱中，在约12.17°、约14.15°、约15.27°、约16.84°、约17.91°、约20.81°处有衍射峰；例如，该结晶在约7.93°、约9.04°、约12.17°、约14.15°、约15.27°、约16.84°、约17.91°、约20.81°、约21.44°、约26.38°处有衍射峰。本发明还提供了该药物组合物的制备方法。还提供了该药物组合物的制药用途。本发明方法制备得到的制备劳拉西泮的新晶型以及药物组合物呈现例如本发明说明书所述优良性能。
摘要（英）：

The invention relates to a light-stabilized pharmaceutical composition, and a preparation method and pharmaceutical application thereof. Specifically, the pharmaceutical composition comprises a lorazepam crystal and pharmaceutical adjuvants. The lorazepam crystal is radiated by Cu-K alpha. In a powder X-ray diffraction pattern expressed by an angle of 2 theta, there are diffraction peaks at approximately 12.17 degrees, approximately 14.15 degrees, approximately 15.27 degrees, approximately 16.84 degrees, approximately 17.91 degrees and approximately 20.81 degrees. For example, the crystal hasdiffraction peaks at approximately 7.93 degrees, approximately 9.04 degrees, approximately 12.17 degrees, approximately 14.15 degrees, approximately 15.27 degrees, approximately 16.84 degrees, approximately 17.91 degrees, approximately 20.81 degrees, approximately 21.44 degrees and approximately 26.38 degrees. A new crystal form and the pharmaceutical composition, which are used for preparing lorazepam and prepared by the method, exhibit excellent properties as described in the description of the invention.

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