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发明公开
CN1706786A 2－甲氧基－5碘苯酚的合成方法 失效 - 权利终止

2－甲氧基－5碘苯酚的合成方法
摘要：
本发明涉及一种2－甲氧基－5碘苯酚的合成方法。本发明方法分三步进行，首先以2－甲氧基－苯酚和对甲苯磺酰氯为反应物，以三乙胺为溶剂，制备对甲苯磺酸－(2－甲氧基)苯酚酯；然后用对甲苯磺酸(2－甲氧基)苯酚酯与金属氯化物及一氯化碘反应，至有大量固体生成；抽滤，冰醋酸洗，水洗；可得对甲苯磺酸－(2－甲氧基－5－碘)苯酚酯；最后对甲苯磺酸(2－甲氧基－5－碘)苯酚酯脱除保护基团得到2－甲氧基－5－碘苯酚。本发明方法具有操作方法简便、试剂价格便宜、苯环的定位效果及产物的分离简便、产率高、和纯度较高的优点，适合于工业生产。
摘要（英）：

The present invention relates to the synthesis process of 2-methoxyl-5-iodophenol. The synthesis process includes the following steps: the reaction of 2-methoxyl-phenol and p-toluenesulfonyl chloride in triethylamine solvent to prepare p-toluenesulfo-(2-methoxyl) phenol ester; the reaction of p-toluenesulfo-(2-methoxyl) phenol ester, metal chloride and iodine monochloride to produce great amount of solid; suction filtering, washing with glacial acetic acid and water washing to obtain p-toluenesulfo-(2-methoxyl-5-iodo) phenol ester; and final deprotection of p-toluenesulfo-(2-methoxyl-5-iodo) phenol ester to obtain 2-methoxyl-5-iodophenol. The present invention has the advantages of simple operation, low material cost, high yield, high product purity, etc. and is suitable for industrial production.

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