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发明授权
CN1764462B T型钙通道阻断剂 失效 - 权利终止 复审申请

T型钙通道阻断剂
摘要：
本发明提供一种T型钙通道阻断剂。具体来说，提供作为下式(1)所示的光学活性1，4-二氢吡啶化合物、其可药用盐或它们的溶剂合物的T型钙通道阻断剂，[式中，R1和R2各自独立地表示C1-6烷基，或者R1和R2结合而表示-CR5R6-CR7R8-、-CR5R6-CR7R8-CR9R10-或者-CR5R6-CR7R8-CR9R10-CR11R12-等，X1或X2各自独立地表示O或NR13，Ar表示可被取代的苯基等，Ra和Rb各自独立地表示C1-6烷基、-L2-NR16R17、-CH2O-L2-NR16R17、CN、-L2-N(CH2CH2)2NR16或NR16R17，Y表示C1-20烷基、-L3-NR18R19、或＊表示绝对构型]。
摘要（英）：

There is provided a T-type calcium channel blocker that is optically active 1,4-dihydropyridine compound, a pharmaceutically acceptable salt thereof or a solvate thereof, of formula (1) wherein R<1> and R<2> are independently of each other C1-6 alkyl group or R<1> and R<2> together form -CR<5>R<6>-CR<7>R<8>-, -CR<5>R<6>-CR<7>R<8>-CR<9>R<10>- or -CR<5>R<6>-CR<7>R<8>-CR<9>R<10>-CR<11>R<12>-, etc.,X<1> and X<2> are independently of each other O or NR<13>, Ar is optionally substituted phenyl group, etc., R and R are independently of each other C1-6 alkyl group, -L<2>-NR<16>R<17>, CH2O-L<2>-NR<16>R<17>, CN, -L<2>-N(CH2CH2)2NR<16> or NR<16>R<17> etc., Y is C1-20 alkyl group, -L<3>-NR<18>R<19> and * is absolute configuration of R.

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