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发明公开
CN1789282A 具有多种功能的多肽 失效 - 权利终止

具有多种功能的多肽
摘要：
本发明涉及如SEQ ID NO：2所示氨基酸序列的多肽或如SEQ ID NO：2的9－27位氨基酸所示的多肽(统称CKLF1 C末端多肽)，以及编码CKLF1 C末端多肽的多核苷酸，含有所述多核苷酸的基因工程载体和宿主细胞。同时，本发明还涉及药物组合物，该药物组合物含有所述多肽或所述多核苷酸、载体、宿主细胞，和/或一种或一种以上药物可接受的盐或药学上可接受的载体或赋形剂。本发明还涉及体外检测来自待测者的样品中本发明所述的多肽或多核苷酸的表达水平是否变化的方法。本发明还涉及与本发明的多肽或其活性片段特异性结合的单克隆或多克隆抗体。本发明的多肽或多核苷酸用于预防和/或治疗HIV感染、过敏性疾病、移植排斥、脑部疾病或自身免疫病。
摘要（英）：

The invention relates to polypeptides of the amino acid sequence represented by SEQ ID NO.2, or polypeptides (CKLF1 C terminal polypeptides) shown by amino acids 9-27 in SEQ ID NO:2, the polynucleotide encoding the CKLF1 C terminal polypeptide, genetic engineering vector and host cell containing the polynucleotide. The invention also relates to a pharmaceutical composition containing the polypeptide or the polypeptide, vector, and host cell, and/or one or more pharmaceutically acceptable salts or pharmaceutically acceptable carriers or excipient. The invention also relates to a method for in vitro detecting whether the expression level of the polypeptide or polynucleotide from detected samples has changed. The invention also relates to the monoclonal or polyclonal antibody specifically binding to the polypeptide or its active fragments. The polypeptides or polynucleotides can be used for the prevention and/or treatment of HIV infection, anaphylactic diseases, implantation repulsion, brain diseases or autoimmune diseases.

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