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发明公开
CN1810831A 一个Arf6激活蛋白及其编码基因与应用 失效 - 权利终止

一个Arf6激活蛋白及其编码基因与应用
摘要：
本发明公开了一个Arf6激活蛋白及其编码基因与应用，其目的是提供一个Arf6激活蛋白及其编码基因与其在抑制Arf6活性中的应用。该蛋白是下述氨基酸残基序列之一：1)序列表中的SEQ ID №：1；2)将序列表中SEQ ID №：1的氨基酸残基序列经过一至十个氨基酸残基的取代、缺失或添加且对Arf6具有激活作用的蛋白质。一种抑制Arf6活性的方法，是将GAP结构域发生点突变或缺失突变的Arf6激活蛋白基因，或将所述Arf6激活蛋白基因的小干扰RNA的编码基因导入宿主，Arf6活性被抑制。本发明的ARFGAP－6及其编码基因将在医学及制药领域发挥重要作用，应用前景广阔。
摘要（英）：

The present invention is one activator protein Arf6 and its coding gene and application in inhibiting the activity of Arf6. The protein has one of the following amino acid residue sequence: 1) SEQ ID No. 1 in the sequence list; and 2. the amino acid residue sequence of SEQ ID No. 1 through substitution, deletion or addition of 1-10 amino acid residues and coding Arf6 activating protein. The Arf6 activity inhibiting method is to introduce Arf6 activator protein gene with point mutated or deletion mutated GAP structure domain or the small interference RNA coding gene of the Arf6 activator protein gene into host so as to inhibit Arf6 activity. The ARFGAP-6 of the present invention and its coding gene will take important role in medical science and medicine preparation.

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