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发明公开
CN1869207A 鼠抗人巨噬细胞迁移抑制因子单克隆抗体及其应用 失效 - 权利终止 转让

鼠抗人巨噬细胞迁移抑制因子单克隆抗体及其应用
摘要：
本发明公开了一种鼠抗人巨噬细胞迁移抑制因子单克隆抗体及其应用。该鼠抗人巨噬细胞迁移抑制因子单克隆抗体，是由杂交瘤细胞株10C3 CGMCC No.1717分泌的单克隆抗体。杂交瘤细胞株10C3 CGMCC No.1717分泌的单克隆抗体、衍生于该单克隆抗体的单链抗体、人－鼠嵌合抗体或Fab片段可以用于治疗败血症，全身炎症反应综和症或急性肺损伤等炎症反应；可以用于治疗类风湿性关节炎，哮喘，多发性硬化症，糖尿病或红斑狼疮等自身免疫性疾病；还可以抑制肿瘤的生成；上述单克隆抗体及其衍生物能够与糖皮质激素联合用药，降低糖皮质激素的用量及副作用。
摘要（英）：

This invention discloses mouse antihuman being macrophage migration inhibition factor monoclonal antibody and its application. The antibody is secreted by hybridoma 10C3 CGMCC No.1717. The monoclonal antibody, single chain antibody that derived from the monoclonal antibody and human-mouse chimeric antibody or Fab segment that secreted by hybridoma 10C3 CGMCC No.1717 can be used to cure septicemia, systemic inflammatory reaction syndromes or acute lung injury and other inflammatory reactions, it also can be used to cure rheumatoid arthritis, asthma, multiple sclerosis, diabetes or lupus erythematosus and other autoimmune diseases, it can also be used to restrain tumor growth. The monoclonal antibody and its derivative can be combined used with glucocorticoid to reduce dosage and side effect of glucocorticoid.

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